ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER
diethyl 2-ethyl-2-phenylmalonate
CAS: 76-67-5
Molecular Formula: C15H20O4
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Names and Identifiers
| Name | diethyl 2-ethyl-2-phenylmalonate |
| Synonyms | TIMTEC-BB SBB008439 ETHYL ETHYLPHENYLMALONATE Diethyl ethylphenylmalonate DIETHYL ETHYLPHENYLMALONATE DIETHYL PHENYL ETHYL MALONATE DIETHYL 2-ETHYL-2-PHENYLMALONATE Diethyl Ethylphenylpropanedioate DIETHYL ETHYLPHENYLPROPANEDIOATE diethyl 2-ethyl-2-phenylmalonate Ethylphenylmalonic acid diethyl ester ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER ethylphenyl-propanedioicacidiethylester phenyl ethyl malonic acid diethylester |
| CAS | 76-67-5 |
| EINECS | 200-978-0 |
| InChI | InChI=1/C15H20O4/c1-4-15(13(16)18-5-2,14(17)19-6-3)12-10-8-7-9-11-12/h7-11H,4-6H2,1-3H3 |
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Physico-chemical Properties
| Molecular Formula | C15H20O4 |
| Molar Mass | 264.32 |
| Density | 1.07 g/mL at 25 °C (lit.) |
| Melting Point | -7 °C |
| Boling Point | 185 °C/15 mmHg (lit.) |
| Flash Point | >230°F |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.00015mmHg at 25°C |
| Appearance | Oil |
| Color | Colourless |
| BRN | 668299 |
| Storage Condition | Refrigerator |
| Refractive Index | n20/D 1.491(lit.) |
| Physical and Chemical Properties | Colorless or yellowish transparent oily liquid. She has abnormal odor. |
| Use | For the pharmaceutical industry |
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29173990 |
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Nature
Open Data Verified Data
colorless or yellowish transparent oily liquid. She has abnormal odor. Density 1.07.1G/cm3. Boiling point of 170 deg C (2. 53kPa). Refractive index 4896. Insoluble in water, soluble in ethanol, ether.
Last Update：2024-01-02 23:10:35
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Preparation Method
Open Data Verified Data
Benzyl Cyanide is reacted with ethanol in the presence of sulfuric acid to form ethyl phenylacetate. After distillation, the obtained ethyl phenylacetate is subjected to condensation reaction with diethyl oxalate and sodium ethoxide, acid-separated by hydrochloric acid, and then subjected to ethylation by bromoethane to form diethyl phenylethylmalonate. Finally, the product is refined by fractional distillation under reduced pressure.
Last Update：2022-01-01 10:33:48
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Use
Open Data Verified Data
A raw material for organic synthesis, which is used as an intermediate for drugs such as phenobarbital and epilepsy.
Last Update：2022-01-01 10:33:47
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Safety
Open Data Verified Data
This product is packaged in an iron drum.
Last Update：2022-01-01 10:33:48
ETHYL(PHENYL)MALONIC ACID DIETHYL ESTER - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | raw material for organic synthesis, used as an intermediate for phenobarbital, epilepsy ketone and other drugs. used in pharmaceutical industry |
| production method | 1. Derived from diethyl phenylmalonate by ethylation. 2. Benzyl Cyanide reacts with ethanol in the presence of sulfuric acid to produce ethyl phenylacetate. After distillation, the obtained ethyl phenylacetate is subjected to condensation reaction with diethyl oxalate and sodium ethoxide, acid-separated by hydrochloric acid, and then subjected to ethylation by bromoethane to form diethyl phenylethylmalonate. Finally, the product is refined by fractional distillation under reduced pressure. Another production method is the condensation of ethyl phenylacetate with diethyl carbonate and bromoethane. |
Last Update：2024-04-10 22:29:15
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Product Name: diethyl 2-ethyl-2-phenylmalonate Request for quotationCAS: 76-67-5
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Email: pules.cn@gmail.com
Mobile: +86-17551318830
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Product Name: Phenobarbital Impurity 26 Request for quotation
CAS: 76-67-5
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QQ: 2853786052
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CAS: 76-67-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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